vOTU vOTU-003738

vOTU: vOTU-003738

Overview

Genome (FASTA) Annotation Track (GFF) Proteins (FASTA) Protein Annotation (TSV)

Cluster properties
vOTU ID	vOTU-003738
Number of genomes	2
Taxonomy (ICTV)	Duplodnaviria → Heunggongvirae → Uroviricota → Caudoviricetes
Taxonomy (UHGV)	vFAM-00044 → vSUBFAM-01046 → vGENUS-00965 → vSUBGEN-02406 → vOTU-003738
Host lineage	Bacteria → Firmicutes_A → Clostridia → Lachnospirales → Lachnospiraceae → Agathobacter → Agathobacter rectalis
Host range breadth	Species
Lifestyle	lytic (evidence: BACPHLIP)

Representative genome
Genome ID	UHGV-0033269
Biosample ID	SAMEA4765639
Genome length (bp)	137,482 bps
CheckV completeness	100.00% (Complete)
CDS count	182
CDS density	85.08%
tRNA count	16
Integrase	No
Viral confidence	Confident

Host assignment details
Assignment method	CRISPR
CRISPR-predicted host lineage	Bacteria → Firmicutes_A → Clostridia → Lachnospirales → Lachnospiraceae → Agathobacter → Agathobacter rectalis	Total connections	19	Host agreement	100
PHIST-predicted host lineage		Total connections		Host agreement

Representative genome content

Select to view: Genome Viewer Functional Annotation

Genome view (completeness: 100)

Functional Annotation

Reference	Gene ID	Reference ID	Bit-score	E-value	Information	Category
KOfam	UHGV-0033269_1	K05636	44.6	0.00000000000056	LAMB1; laminin, beta 1	N/A
PHROG	UHGV-0033269_1	phrog_4211	50.0	0.000000000000012	tail length tape measure protein	tail
eggNOG-mapper	UHGV-0033269_1	1274524.BSONL12_21499	61.2	0.00000153	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	N/A
COG	UHGV-0033269_1	COG0739	N/A	N/A	Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contains LysM domain	N/A
structural_annotation	UHGV-0033269_2	PF02010,MF_00075,MF_04116,NF040788	N/A	N/A	N/A	N/A
Pfam	UHGV-0033269_3	PF09479	N/A	N/A	Listeria-Bacteroides repeat domain (List_Bact_rpt)	Flg_new
COG	UHGV-0033269_3	COG2247	N/A	N/A	Putative cell wall-binding domain (amidase enhancer), LytB superfamily	N/A
structural_annotation	UHGV-0033269_3	NF033189	N/A	N/A	N/A	N/A
structural_annotation	UHGV-0033269_4	PF19077,PF19266,PF13157,PF00041,MF_04116,MF_01591,NF041335,COG3499,COG2372	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_5	phrog_32343	92.7	2.8026e-45	N/A	unknown function
UniRef90	UHGV-0033269_5	UniRef90_A0A345BPW9	312.0	0	Putative flagellin-like protein	N/A
eggNOG-mapper	UHGV-0033269_5	1235800.C819_00529	61.2	0.00000125	N/A	N/A
structural_annotation	UHGV-0033269_5	PF05113,NF033848,COG4379	N/A	N/A	N/A	N/A
eggNOG-mapper	UHGV-0033269_7	1519439.JPJG01000060_gene1892	58.9	0.00000421	Collagen triple helix repeat (20 copies)	N/A
COG	UHGV-0033269_7	COG3064	N/A	N/A	Membrane protein TolA involved in colicin uptake	N/A
structural_annotation	UHGV-0033269_11	PF19789	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_12	phrog_37900	294.1	0	N/A	unknown function
UniRef90	UHGV-0033269_12	UniRef90_A0A1Q6PTZ1	223.0	0	N/A	N/A
eggNOG-mapper	UHGV-0033269_12	552398.HMPREF0866_03098	221.0	0	N/A	N/A
Pfam	UHGV-0033269_12	PF19789	N/A	N/A	N/A	DUF6273
COG	UHGV-0033269_12	COG3827	N/A	N/A	Cell pole-organizing protein PopZ	N/A
structural_annotation	UHGV-0033269_12	PF19789	N/A	N/A	N/A	N/A
Pfam	UHGV-0033269_14	PF09682	N/A	N/A	Bacteriophage holin of superfamily 6 (Holin_LLH)	Phage_holin_6_1
structural_annotation	UHGV-0033269_14	PF09682,TIGR01673	N/A	N/A	N/A	N/A
eggNOG-mapper	UHGV-0033269_16	476272.RUMHYD_01953	76.3	2.45e-17	N/A	N/A
PHROG	UHGV-0033269_18	phrog_59	146.9	6.16571e-44	HNH endonuclease	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_18	UniRef90_S4DEV2	116.0	2.75e-30	HNH endonuclease domain protein	N/A
eggNOG-mapper	UHGV-0033269_18	1260356.D920_01718	116.0	4.61e-31	HNH endonuclease	N/A
PADLOC	UHGV-0033269_18	HEase_00016	64.0	4.1e-18	homing endonuclease	RM
Pfam	UHGV-0033269_18	PF13392	N/A	N/A	HNH endonuclease	HNH_3
PHROG	UHGV-0033269_19	phrog_16490	51.2	0.0000000000000019	N/A	unknown function
eggNOG-mapper	UHGV-0033269_19	1408437.JNJN01000043_gene803	68.9	0.0000000000131	N/A	N/A
PHROG	UHGV-0033269_20	phrog_20016	183.6	0	N/A	unknown function
UniRef90	UHGV-0033269_20	UniRef90_A0A345BPX4	159.0	0	Carbohydrate binding domain/collagen triple helix repeat protein	N/A
eggNOG-mapper	UHGV-0033269_20	1226322.HMPREF1545_00077	165.0	0	N/A	N/A
structural_annotation	UHGV-0033269_20	PF18573,NF033147	N/A	N/A	N/A	N/A
eggNOG-mapper	UHGV-0033269_21	658655.HMPREF0988_00915	75.1	0.00000000000004	N/A	N/A
PHROG	UHGV-0033269_22	phrog_1233	56.2	6.2e-16	N/A	unknown function
UniRef90	UHGV-0033269_22	UniRef90_A0A345BPX6	140.0	2.10994e-41	Metal-dependent hydrolase	N/A
eggNOG-mapper	UHGV-0033269_22	658655.HMPREF0988_00914	84.3	8.8e-20	N/A	N/A
eggNOG-mapper	UHGV-0033269_24	871968.DESME_08990	56.2	0.00000000729	N/A	N/A
KOfam	UHGV-0033269_25	K01520	137.4	9.99995e-41	dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23]	N/A
PHROG	UHGV-0033269_25	phrog_135	152.3	1.4013e-45	dUTPase	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_25	UniRef90_A0A8D9UHK3	154.0	1.4013e-45	dUTPase	N/A
eggNOG-mapper	UHGV-0033269_25	622312.ROSEINA2194_00085	139.0	1.55e-40	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	N/A
Pfam	UHGV-0033269_25	PF00692	N/A	N/A	dUTPase	dUTPase
NCBIFam	UHGV-0033269_25	TIGR00576.1	N/A	N/A	dUTP diphosphatase	N/A
COG	UHGV-0033269_25	COG0756	N/A	N/A	dUTP pyrophosphatase (dUTPase)	N/A
structural_annotation	UHGV-0033269_25	PF00692,MF_00116,TIGR00576,COG0756	N/A	N/A	N/A	N/A
structural_annotation	UHGV-0033269_27	PF14639,MF_00651,NF001026,COG0816	N/A	N/A	N/A	N/A
KOfam	UHGV-0033269_30	K00525	449.3	0	E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]	N/A
PHROG	UHGV-0033269_30	phrog_84	272.0	0	ribonucleoside-diphosphate reductase large subunit	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_30	UniRef90_UPI00085BFD37	692.0	0	adenosylcobalamin-dependent ribonucleoside-diphosphate reductase	N/A
eggNOG-mapper	UHGV-0033269_30	537013.CLOSTMETH_03946	685.0	0	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	N/A
Pfam	UHGV-0033269_30	PF02867	N/A	N/A	Ribonucleotide reductase, barrel domain	Ribonuc_red_lgC
COG	UHGV-0033269_30	COG0209	N/A	N/A	Ribonucleotide reductase alpha subunit	N/A
structural_annotation	UHGV-0033269_30	PF02867,MF_04026,NF006417,COG0209	N/A	N/A	N/A	N/A
KOfam	UHGV-0033269_31	K00942	91.6	1.1e-26	gmk, GUK1; guanylate kinase [EC:2.7.4.8]	N/A
PHROG	UHGV-0033269_31	phrog_1815	106.7	2.8e-31	guanylate kinase	other
UniRef90	UHGV-0033269_31	UniRef90_A0A401UTJ7	110.0	5.65e-27	Guanylate kinase	N/A
eggNOG-mapper	UHGV-0033269_31	742733.HMPREF9469_00862	86.3	1.44e-18	Guanylate kinase homologues.	N/A
Pfam	UHGV-0033269_31	PF00625	N/A	N/A	Guanylate kinase	Guanylate_kin
COG	UHGV-0033269_31	COG0194	N/A	N/A	Guanylate kinase	N/A
structural_annotation	UHGV-0033269_31	PF00625,MF_00328,TIGR03263,COG0194	N/A	N/A	N/A	N/A
KOfam	UHGV-0033269_32	K02337	541.3	0	dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	N/A
PHROG	UHGV-0033269_32	phrog_405	677.6	0	DNA polymerase	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_32	UniRef90_A0A843FMN7	1424.0	0	DNA-directed DNA polymerase	N/A
eggNOG-mapper	UHGV-0033269_32	224308.BSU20340	913.0	0	DNA polymerase	N/A
Pfam	UHGV-0033269_32	PF02811	N/A	N/A	PHP domain	PHP
Pfam	UHGV-0033269_32	PF07733	N/A	N/A	Bacterial DNA polymerase III alpha NTPase domain	DNA_pol3_alpha
Pfam	UHGV-0033269_32	PF17657	N/A	N/A	Bacterial DNA polymerase III alpha subunit finger domain	DNA_pol3_finger
Pfam	UHGV-0033269_32	PF14579	N/A	N/A	Helix-hairpin-helix motif	HHH_6
COG	UHGV-0033269_32	COG0587	N/A	N/A	DNA polymerase III, alpha subunit	N/A
structural_annotation	UHGV-0033269_32	PF07733,PF02811,PF17657,PF14579,MF_01902,NF005617,COG0587	N/A	N/A	N/A	N/A
KOfam	UHGV-0033269_33	K03581	98.7	2e-29	recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]	N/A
PHROG	UHGV-0033269_33	phrog_325	180.2	0	Dda-like helicase	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_33	UniRef90_A0A345BPZ9	273.0	0	ATP-dependent exoDNAse, alpha	N/A
eggNOG-mapper	UHGV-0033269_33	1220582.RRU01S_04_01100	151.0	5.99e-40	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member	N/A
Pfam	UHGV-0033269_33	PF13604	N/A	N/A	AAA domain	AAA_30
Pfam	UHGV-0033269_33	PF13538	N/A	N/A	UvrD-like helicase C-terminal domain	UvrD_C_2
COG	UHGV-0033269_33	COG0507	N/A	N/A	ATPase/5'-3' helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V)	N/A
structural_annotation	UHGV-0033269_33	MF_03176,TIGR01447	N/A	N/A	N/A	N/A
UniRef90	UHGV-0033269_34	UniRef90_A0A843FTG5	154.0	2.04029e-42	Phage_lysozyme2 domain-containing protein	N/A
eggNOG-mapper	UHGV-0033269_34	562983.HMPREF0433_01500	56.2	0.000000568	domain protein	N/A
Pfam	UHGV-0033269_34	PF18013	N/A	N/A	Phage tail lysozyme	Phage_lysozyme2
COG	UHGV-0033269_34	COG3583	N/A	N/A	N/A	N/A
structural_annotation	UHGV-0033269_34	PF18013,PF02185,NF001260	N/A	N/A	N/A	N/A
KOfam	UHGV-0033269_35	K07462	289.2	0	recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]	N/A
PHROG	UHGV-0033269_35	phrog_2484	422.3	0	RecJ-like ssDNA exonuclease	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_35	UniRef90_A0A843FU26	556.0	0	DHH family phosphoesterase	N/A
eggNOG-mapper	UHGV-0033269_35	665956.HMPREF1032_03163	322.0	0	exonuclease	N/A
Pfam	UHGV-0033269_35	PF01368	N/A	N/A	DHH family	DHH
Pfam	UHGV-0033269_35	PF17768	N/A	N/A	RecJ OB domain	RecJ_OB
COG	UHGV-0033269_35	COG0608	N/A	N/A	ssDNA-specific exonuclease RecJ, DHH superfamily, may be involved in archaeal DNA replication intiation	N/A
structural_annotation	UHGV-0033269_35	PF17768,PF02272,MF_00207,TIGR00644,COG0608	N/A	N/A	N/A	N/A
KOfam	UHGV-0033269_36	K02316	53.8	0.0000000000000018	dnaG; DNA primase [EC:2.7.7.101]	N/A
PHROG	UHGV-0033269_36	phrog_47	106.6	3e-31	DNA primase	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_36	UniRef90_A0A345BPU0	301.0	0	DNA primase	N/A
eggNOG-mapper	UHGV-0033269_36	1280.SAXN108_2224	205.0	0	DNA primase activity	N/A
COG	UHGV-0033269_36	COG0358	N/A	N/A	DNA primase (bacterial type)	N/A
structural_annotation	UHGV-0033269_36	PF01807,PF19898,MF_00974,NF006382,COG0358	N/A	N/A	N/A	N/A
UniRef90	UHGV-0033269_38	UniRef90_A0A345BPT8	81.3	2.68e-18	Replicative DNA helicase	N/A
COG	UHGV-0033269_38	COG0305	N/A	N/A	Replicative DNA helicase	N/A
PHROG	UHGV-0033269_39	phrog_7168	100.0	1e-30	homing endonuclease	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_39	UniRef90_A0A345BPT7	184.0	0	HNH endonuclease domain protein	N/A
eggNOG-mapper	UHGV-0033269_39	742735.HMPREF9467_00770	71.2	0.00000000000508	GIY-YIG type nucleases (URI domain)	N/A
PADLOC	UHGV-0033269_39	HEase_00030	51.4	0.000000000000032	homing endonuclease	RM
Pfam	UHGV-0033269_39	PF01541	N/A	N/A	GIY-YIG catalytic domain	GIY-YIG
NCBIFam	UHGV-0033269_39	TIGR01453.1	N/A	N/A	group I intron endonuclease	N/A
structural_annotation	UHGV-0033269_39	PF19835,PF03683,TIGR01453,COG2886	N/A	N/A	N/A	N/A
eggNOG-mapper	UHGV-0033269_40	537007.BLAHAN_05495	74.3	0.0000000000000144	DnaB-like helicase C terminal domain	N/A
COG	UHGV-0033269_40	COG0305	N/A	N/A	Replicative DNA helicase	N/A
KOfam	UHGV-0033269_42	K02314	65.5	6.5e-19	dnaB; replicative DNA helicase [EC:5.6.2.3]	N/A
PHROG	UHGV-0033269_42	phrog_19	91.6	7.5e-27	DnaB-like replicative helicase	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_42	UniRef90_A0A843FNV1	407.0	0	DNA helicase	N/A
eggNOG-mapper	UHGV-0033269_42	742735.HMPREF9467_00891	231.0	0	DnaB-like helicase C terminal domain	N/A
Pfam	UHGV-0033269_42	PF00772	N/A	N/A	DnaB-like helicase N terminal domain	DnaB
Pfam	UHGV-0033269_42	PF03796	N/A	N/A	DnaB-like helicase C terminal domain	DnaB_C
COG	UHGV-0033269_42	COG0305	N/A	N/A	Replicative DNA helicase	N/A
structural_annotation	UHGV-0033269_42	PF03796,PF00772,MF_04155,TIGR00665,COG0305	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_43	phrog_124	138.2	4.69996e-41	Sak4-like ssDNA annealing protein	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_43	UniRef90_A0A843GMB3	233.0	0	ATP-binding protein	N/A
eggNOG-mapper	UHGV-0033269_43	1541960.KQ78_01919	168.0	0	Belongs to the helicase family. UvrD subfamily	N/A
Pfam	UHGV-0033269_43	PF13479	N/A	N/A	AAA domain	AAA_24
COG	UHGV-0033269_43	COG2887	N/A	N/A	RecB family exonuclease	N/A
structural_annotation	UHGV-0033269_43	PF13479,MF_00350,TIGR01618,COG0468	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_44	phrog_4645	138.8	2.50006e-41	endonuclease	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_44	UniRef90_A0A345BQ04	114.0	5.41e-26	LAGLIDADG-like domain protein	N/A
eggNOG-mapper	UHGV-0033269_44	1235659.S4T8V2_9CAUD	73.2	0.00000000000423	N-acetyltransferase activity	N/A
Pfam	UHGV-0033269_44	PF14528	N/A	N/A	LAGLIDADG-like domain	LAGLIDADG_3
structural_annotation	UHGV-0033269_44	PF03161,PF02796,MF_01420,TIGR00647,TIGR04381,COG1372	N/A	N/A	N/A	N/A
structural_annotation	UHGV-0033269_46	PF00436,PF19649,MF_00984,NF004476,COG2965	N/A	N/A	N/A	N/A
KOfam	UHGV-0033269_47	K03465	97.8	1.1e-28	thyX, thy1; thymidylate synthase (FAD) [EC:2.1.1.148]	N/A
PHROG	UHGV-0033269_47	phrog_85	54.0	0.0000000000000024	thymidylate synthase	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_47	UniRef90_A0A7X2NTD7	304.0	0	FAD-dependent thymidylate synthase	N/A
eggNOG-mapper	UHGV-0033269_47	1282887.AUJG01000001_gene1906	285.0	0	thymidylate synthase (FAD) activity	N/A
Pfam	UHGV-0033269_47	PF02511	N/A	N/A	Thymidylate synthase complementing protein	Thy1
COG	UHGV-0033269_47	COG1351	N/A	N/A	Thymidylate synthase ThyX, FAD-dependent family	N/A
structural_annotation	UHGV-0033269_47	PF02511,MF_01408,TIGR02170,COG1351	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_48	phrog_314	87.8	1.9e-25	homing endonuclease	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_48	UniRef90_A0A345BPZ2	136.0	1.9e-34	GIY-YIG domain-containing protein	N/A
PADLOC	UHGV-0033269_48	HEase_00030	44.6	0.0000000000026	homing endonuclease	RM
Pfam	UHGV-0033269_48	PF01541	N/A	N/A	GIY-YIG catalytic domain	GIY-YIG
NCBIFam	UHGV-0033269_48	TIGR01453.1	N/A	N/A	group I intron endonuclease	N/A
COG	UHGV-0033269_48	COG3860	N/A	N/A	N/A	N/A
structural_annotation	UHGV-0033269_48	PF19835,TIGR01453	N/A	N/A	N/A	N/A
structural_annotation	UHGV-0033269_49	PF04182,MF_01909,NF040939,COG1675	N/A	N/A	N/A	N/A
KOfam	UHGV-0033269_52	K10747	93.9	1e-27	LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]	N/A
PHROG	UHGV-0033269_52	phrog_114	135.7	3.4e-40	ATP-dependent DNA ligase	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_52	UniRef90_A0A345BPZ1	312.0	0	DNA ligase	N/A
eggNOG-mapper	UHGV-0033269_52	1121121.KB894295_gene4492	181.0	0	dna ligase	N/A
Pfam	UHGV-0033269_52	PF01068	N/A	N/A	ATP dependent DNA ligase domain	DNA_ligase_A_M
COG	UHGV-0033269_52	COG1793	N/A	N/A	ATP-dependent DNA ligase	N/A
structural_annotation	UHGV-0033269_52	PF01068,MF_00407,TIGR02779,COG1793	N/A	N/A	N/A	N/A
KOfam	UHGV-0033269_53	K02469	627.3	0	gyrA; DNA gyrase subunit A [EC:5.6.2.2]	N/A
PHROG	UHGV-0033269_53	phrog_551	330.5	0	DNA topoisomerase II	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_53	UniRef90_A0A350R878	419.0	0	DNA gyrase subunit A	N/A
eggNOG-mapper	UHGV-0033269_53	1541960.KQ78_01979	410.0	0	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	N/A
Pfam	UHGV-0033269_53	PF00521	N/A	N/A	DNA gyrase/topoisomerase IV, subunit A	DNA_topoisoIV
Pfam	UHGV-0033269_53	PF03989	N/A	N/A	DNA gyrase C-terminal domain, beta-propeller	DNA_gyraseA_C
COG	UHGV-0033269_53	COG0188	N/A	N/A	DNA gyrase/topoisomerase IV, subunit A	N/A
structural_annotation	UHGV-0033269_53	PF00521,PF03989,MF_01897,NF004043,COG0188	N/A	N/A	N/A	N/A
KOfam	UHGV-0033269_54	K02470	609.1	0	gyrB; DNA gyrase subunit B [EC:5.6.2.2]	N/A
PHROG	UHGV-0033269_54	phrog_543	508.1	0	DNA topoisomerase II large subunit	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_54	UniRef90_A0A345BPY9	522.0	0	DNA topoisomerase (ATP-hydrolyzing)	N/A
eggNOG-mapper	UHGV-0033269_54	689781.AUJX01000045_gene2658	409.0	0	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	N/A
Pfam	UHGV-0033269_54	PF02518	N/A	N/A	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	HATPase_c
Pfam	UHGV-0033269_54	PF00204	N/A	N/A	DNA gyrase B	DNA_gyraseB
Pfam	UHGV-0033269_54	PF01751	N/A	N/A	Toprim domain	Toprim
Pfam	UHGV-0033269_54	PF00986	N/A	N/A	DNA gyrase B subunit, carboxyl terminus	DNA_gyraseB_C
COG	UHGV-0033269_54	COG0187	N/A	N/A	DNA gyrase/topoisomerase IV, subunit B	N/A
structural_annotation	UHGV-0033269_54	PF00204,MF_01898,TIGR01059,COG0187	N/A	N/A	N/A	N/A
KOfam	UHGV-0033269_55	K03469	132.1	4.9e-39	rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4]	N/A
PHROG	UHGV-0033269_55	phrog_531	131.6	4e-39	Rnase H	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_55	UniRef90_A0A843FJ64	122.0	1.99e-32	Ribonuclease H	N/A
eggNOG-mapper	UHGV-0033269_55	1121451.DESAM_20563	95.9	5.71e-23	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	N/A
Pfam	UHGV-0033269_55	PF00075	N/A	N/A	RNase H	RNase_H
COG	UHGV-0033269_55	COG0328	N/A	N/A	Ribonuclease HI	N/A
structural_annotation	UHGV-0033269_55	PF00075,MF_00042,NF001236,COG0328	N/A	N/A	N/A	N/A
KOfam	UHGV-0033269_57	K01448	44.5	0.0000000000016	amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	N/A
PHROG	UHGV-0033269_57	phrog_9589	72.5	1.6e-26	endolysin	lysis
eggNOG-mapper	UHGV-0033269_57	552398.HMPREF0866_03091	145.0	6.15e-37	CHAP domain	N/A
Pfam	UHGV-0033269_57	PF01471	N/A	N/A	Putative peptidoglycan binding domain	PG_binding_1
Pfam	UHGV-0033269_57	PF05257	N/A	N/A	CHAP domain	CHAP
COG	UHGV-0033269_57	COG0791	N/A	N/A	Cell wall-associated hydrolase, NlpC_P60 family	N/A
KOfam	UHGV-0033269_58	K07175	157.2	0	phoH2; PhoH-like ATPase	N/A
PHROG	UHGV-0033269_58	phrog_2765	209.0	0	PhoH-like phosphate starvation-inducible	other
UniRef90	UHGV-0033269_58	UniRef90_A0A1C5UCD2	431.0	0	PhoH-like protein	N/A
eggNOG-mapper	UHGV-0033269_58	1123252.ATZF01000010_gene420	270.0	0	PIN domain	N/A
Pfam	UHGV-0033269_58	PF02562	N/A	N/A	PhoH-like protein	PhoH
COG	UHGV-0033269_58	COG1875	N/A	N/A	Predicted ribonuclease YlaK, contains NYN-type RNase and PhoH-family ATPase domains	N/A
structural_annotation	UHGV-0033269_58	PF02562,PF13638,PF09142,MF_00265,NF007827,NF009148,COG1875	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_61	phrog_547	89.5	2.8e-26	phosphoesterase	other
UniRef90	UHGV-0033269_61	UniRef90_A0A1I0M725	156.0	5.60519e-45	Calcineurin-like phosphoesterase superfamily protein	N/A
eggNOG-mapper	UHGV-0033269_61	445961.IW15_14075	68.2	0.0000000000177	Calcineurin-like phosphoesterase superfamily domain	N/A
COG	UHGV-0033269_61	COG4186	N/A	N/A	N/A	N/A
structural_annotation	UHGV-0033269_61	PF12850,MF_00575,NF006988,COG4186	N/A	N/A	N/A	N/A
KOfam	UHGV-0033269_63	K15456	55.3	8.3e-16	KTI12; protein KTI12	N/A
PHROG	UHGV-0033269_63	phrog_6931	83.0	3.2e-24	N/A	unknown function
UniRef90	UHGV-0033269_63	UniRef90_A0A345BPY6	89.4	2.69e-19	AAA domain protein	N/A
eggNOG-mapper	UHGV-0033269_63	1347368.HG964410_gene7506	69.3	0.0000000000109	Chromatin associated protein KTI12	N/A
Pfam	UHGV-0033269_63	PF08433	N/A	N/A	Chromatin associated protein KTI12	KTI12
COG	UHGV-0033269_63	COG2844	N/A	N/A	UTP:GlnB (protein PII) uridylyltransferase	N/A
structural_annotation	UHGV-0033269_63	PF13671,MF_00065,TIGR03574,COG4088	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_64	phrog_1257	46.8	0.0000000000005	ribosome associated inhibitor A; zinc finger domain	moron, auxiliary metabolic gene and host takeover
structural_annotation	UHGV-0033269_66	PF01978,MF_01177,NF008240,COG0735	N/A	N/A	N/A	N/A
KOfam	UHGV-0033269_69	K18961	136.4	9.70007e-41	rnlA; T4 RNA ligase 1 [EC:6.5.1.3]	N/A
PHROG	UHGV-0033269_69	phrog_562	179.1	0	RNA ligase and tail fiber protein attachment catalyst	tail
UniRef90	UHGV-0033269_69	UniRef90_D8FWV8	190.0	0	Putative RNA ligase (ATP)	N/A
eggNOG-mapper	UHGV-0033269_69	402777.KB235903_gene825	190.0	0	RNA ligase	N/A
Pfam	UHGV-0033269_69	PF09511	N/A	N/A	RNA ligase	RNA_lig_T4_1
structural_annotation	UHGV-0033269_69	PF09511,MF_04149,TIGR02308,COG5324	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_70	phrog_547	67.9	6.6e-22	phosphoesterase	other
UniRef90	UHGV-0033269_70	UniRef90_A0A843FNF2	228.0	0	Metallophosphoesterase	N/A
eggNOG-mapper	UHGV-0033269_70	1410632.JHWW01000019_gene1481	143.0	4.94e-40	N/A	N/A
Pfam	UHGV-0033269_70	PF00149	N/A	N/A	Calcineurin-like phosphoesterase	Metallophos
structural_annotation	UHGV-0033269_70	MF_00575,TIGR04123,COG4186	N/A	N/A	N/A	N/A
KOfam	UHGV-0033269_72	K00600	571.4	0	glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1]	N/A
PHROG	UHGV-0033269_72	phrog_9968	480.1	0	methyltransferase	other
UniRef90	UHGV-0033269_72	UniRef90_A0A354UC54	483.0	0	Serine hydroxymethyltransferase	N/A
eggNOG-mapper	UHGV-0033269_72	858215.Thexy_0455	426.0	0	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	N/A
Pfam	UHGV-0033269_72	PF00464	N/A	N/A	Serine hydroxymethyltransferase	SHMT
NCBIFam	UHGV-0033269_72	NF000586.1	N/A	N/A	serine hydroxymethyltransferase	N/A
COG	UHGV-0033269_72	COG0112	N/A	N/A	Glycine/serine hydroxymethyltransferase	N/A
HAMAP	UHGV-0033269_72	MF_00051	N/A	N/A	Serine hydroxymethyltransferase [glyA]	N/A
structural_annotation	UHGV-0033269_72	PF00464,MF_00051,NF000586,COG0112	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_75	phrog_2470	46.7	0.00000000000038	membrane protein	moron, auxiliary metabolic gene and host takeover
UniRef90	UHGV-0033269_75	UniRef90_UPI000495118B	130.0	7.05e-37	N/A	N/A
eggNOG-mapper	UHGV-0033269_75	742735.HMPREF9467_00878	124.0	4.67e-35	N/A	N/A
structural_annotation	UHGV-0033269_79	PF14354,TIGR03655	N/A	N/A	N/A	N/A
Pfam	UHGV-0033269_83	PF13240	N/A	N/A	zinc-ribbon domain	zinc_ribbon_2
PHROG	UHGV-0033269_86	phrog_839	49.5	0.000000000000034	N/A	unknown function
KOfam	UHGV-0033269_90	K07313	90.3	2.1e-26	pphA; serine/threonine protein phosphatase 1 [EC:3.1.3.16]	N/A
PHROG	UHGV-0033269_90	phrog_246	72.6	4.2e-21	NinI-like serine-threonine phosphatase	other
UniRef90	UHGV-0033269_90	UniRef90_R6LQ90	174.0	0	Metallophos domain-containing protein	N/A
eggNOG-mapper	UHGV-0033269_90	500633.CLOHIR_00780	152.0	1.04957e-42	phosphoprotein phosphatase activity	N/A
Pfam	UHGV-0033269_90	PF00149	N/A	N/A	Calcineurin-like phosphoesterase	Metallophos
COG	UHGV-0033269_90	COG0639	N/A	N/A	Diadenosine tetraphosphatase ApaH/serine/threonine protein phosphatase, PP2A family	N/A
structural_annotation	UHGV-0033269_90	PF12850,MF_01443,NF007425,COG0622	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_93	phrog_1479	58.4	1.3e-16	N/A	unknown function
eggNOG-mapper	UHGV-0033269_93	1256908.HMPREF0373_01589	96.7	6.67e-25	N/A	N/A
Pfam	UHGV-0033269_93	PF20274	N/A	N/A	Cyclic-phosphate processing Receiver domain	cREC_REC
structural_annotation	UHGV-0033269_93	PF20274	N/A	N/A	N/A	N/A
structural_annotation	UHGV-0033269_94	PF01978,MF_01819,NF012168,COG0735	N/A	N/A	N/A	N/A
Pfam	UHGV-0033269_99	PF18454	N/A	N/A	Major tropism determinant N-terminal domain	Mtd_N
PHROG	UHGV-0033269_100	phrog_33094	40.3	0.000000000064	N/A	unknown function
PHROG	UHGV-0033269_101	phrog_35541	130.3	1.3e-40	N/A	unknown function
UniRef90	UHGV-0033269_101	UniRef90_A0A3D6B2G4	181.0	0	Mtd_N domain-containing protein	N/A
structural_annotation	UHGV-0033269_101	PF18454	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_102	phrog_27786	49.5	0.000000000000041	tail spike protein	tail
UniRef90	UHGV-0033269_102	UniRef90_A0A6J5LI95	55.5	0.00000106	Mtd_N domain-containing protein	N/A
eggNOG-mapper	UHGV-0033269_102	679935.Alfi_2724	62.8	0.00000000124	N/A	N/A
Pfam	UHGV-0033269_102	PF18454	N/A	N/A	Major tropism determinant N-terminal domain	Mtd_N
structural_annotation	UHGV-0033269_102	PF18454	N/A	N/A	N/A	N/A
structural_annotation	UHGV-0033269_103	PF20010	N/A	N/A	N/A	N/A
structural_annotation	UHGV-0033269_104	PF13973,NF038082,COG4728	N/A	N/A	N/A	N/A
Pfam	UHGV-0033269_105	PF13529	N/A	N/A	Peptidase_C39 like family	Peptidase_C39_2
structural_annotation	UHGV-0033269_108	MF_00085,NF008465	N/A	N/A	N/A	N/A
structural_annotation	UHGV-0033269_122	PF11314	N/A	N/A	N/A	N/A
structural_annotation	UHGV-0033269_126	PF02581,MF_02232,TIGR01182,COG0135	N/A	N/A	N/A	N/A
eggNOG-mapper	UHGV-0033269_128	935948.KE386495_gene2241	65.1	0.0000000159	N/A	N/A
Pfam	UHGV-0033269_131	PF01541	N/A	N/A	GIY-YIG catalytic domain	GIY-YIG
KOfam	UHGV-0033269_133	K06284	41.1	0.000000000025	abrB; AbrB family transcriptional regulator, transcriptional pleiotropic regulator of transition state genes	N/A
PHROG	UHGV-0033269_133	phrog_4681	41.6	0.0000000000083	antitoxin from a toxin-antitoxin system	moron, auxiliary metabolic gene and host takeover
Pfam	UHGV-0033269_133	PF04014	N/A	N/A	Antidote-toxin recognition MazE, bacterial antitoxin	MazE_antitoxin
NCBIFam	UHGV-0033269_133	TIGR01439.1	N/A	N/A	transcriptional regulator, AbrB family	N/A
COG	UHGV-0033269_133	COG2002	N/A	N/A	Bifunctional DNA-binding transcriptional regulator of stationary/sporulation/toxin gene expression and antitoxin component of the YhaV-PrlF toxin-antitoxin module	N/A
PHROG	UHGV-0033269_138	phrog_20187	171.6	0	N/A	unknown function
UniRef90	UHGV-0033269_138	UniRef90_A0A345BPQ2	104.0	8.42e-23	Putative Pol III-like exoribonuclease	N/A
structural_annotation	UHGV-0033269_138	PF03104,MF_00045,TIGR00573,COG1949	N/A	N/A	N/A	N/A
structural_annotation	UHGV-0033269_141	PF11019,MF_01022,NF003937,COG4502	N/A	N/A	N/A	N/A
structural_annotation	UHGV-0033269_142	PF08962	N/A	N/A	N/A	N/A
KOfam	UHGV-0033269_151	K04769	93.1	4.4e-27	spoVT; AbrB family transcriptional regulator, stage V sporulation protein T	N/A
PHROG	UHGV-0033269_151	phrog_4681	75.1	5.6e-22	antitoxin from a toxin-antitoxin system	moron, auxiliary metabolic gene and host takeover
UniRef90	UHGV-0033269_151	UniRef90_A0A8A5ZJD8	83.6	3.23e-19	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	N/A
eggNOG-mapper	UHGV-0033269_151	1235835.C814_03375	79.7	1.94e-17	stage V sporulation protein T	N/A
Pfam	UHGV-0033269_151	PF04014	N/A	N/A	Antidote-toxin recognition MazE, bacterial antitoxin	MazE_antitoxin
NCBIFam	UHGV-0033269_151	TIGR01439.1	N/A	N/A	transcriptional regulator, AbrB family	N/A
COG	UHGV-0033269_151	COG2002	N/A	N/A	Bifunctional DNA-binding transcriptional regulator of stationary/sporulation/toxin gene expression and antitoxin component of the YhaV-PrlF toxin-antitoxin module	N/A
structural_annotation	UHGV-0033269_151	PF04014,TIGR01439,COG2002	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_162	phrog_5767	83.7	1.7e-25	sigma factor	transcription regulation
UniRef90	UHGV-0033269_162	UniRef90_A0A345BPU6	276.0	0	HTH DNA binding domain protein	N/A
PHROG	UHGV-0033269_163	phrog_3314	206.0	0	N/A	unknown function
eggNOG-mapper	UHGV-0033269_163	1308863.U5J9N3_9CAUD	86.7	3.05e-16	N/A	N/A
PHROG	UHGV-0033269_164	phrog_15503	178.8	0	N/A	unknown function
eggNOG-mapper	UHGV-0033269_164	1308863.U5J9B2_9CAUD	88.2	1.04e-17	N/A	N/A
structural_annotation	UHGV-0033269_164	PF05876,COG5410	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_165	phrog_7168	69.8	3.8e-20	homing endonuclease	DNA, RNA and nucleotide metabolism
UniRef90	UHGV-0033269_165	UniRef90_W7RFA3	53.9	0.0000000949	GIY-YIG domain-containing protein (Fragment)	N/A
eggNOG-mapper	UHGV-0033269_165	476272.RUMHYD_01972	64.3	0.0000000000236	GIY-YIG type nucleases (URI domain)	N/A
PADLOC	UHGV-0033269_165	HEase_00030	43.9	0.0000000000079	homing endonuclease	RM
Pfam	UHGV-0033269_165	PF01541	N/A	N/A	GIY-YIG catalytic domain	GIY-YIG
COG	UHGV-0033269_165	COG3860	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_167	phrog_24618	145.6	2.70451e-43	N/A	unknown function
UniRef90	UHGV-0033269_167	UniRef90_A0A0H3V0N0	310.0	0	Putative terminase large subunit	N/A
eggNOG-mapper	UHGV-0033269_167	1235793.C809_01156	103.0	3.36e-21	N/A	N/A
structural_annotation	UHGV-0033269_167	PF20441,MF_04146,TIGR01547,COG5362	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_169	phrog_2739	265.5	0	portal protein	head and packaging
UniRef90	UHGV-0033269_169	UniRef90_A0A345BPV2	435.0	0	Putative portal protein	N/A
eggNOG-mapper	UHGV-0033269_169	665956.HMPREF1032_03237	117.0	2.56e-25	N/A	N/A
structural_annotation	UHGV-0033269_169	PF05133,MF_04135,TIGR01537,COG4695	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_170	phrog_3313	116.4	5.4e-36	N/A	unknown function
UniRef90	UHGV-0033269_170	UniRef90_A0A843FJ52	151.0	5.47e-38	HALZ domain-containing protein	N/A
eggNOG-mapper	UHGV-0033269_170	574375.BAGA_05920	95.9	3.15e-18	N/A	N/A
structural_annotation	UHGV-0033269_170	PF04586,TIGR01543,COG3566	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_171	phrog_35301	46.2	0.000000000000054	N/A	unknown function
PHROG	UHGV-0033269_172	phrog_4088	231.0	0	N/A	unknown function
eggNOG-mapper	UHGV-0033269_172	1541960.KQ78_01850	217.0	0	N/A	N/A
structural_annotation	UHGV-0033269_172	PF05065,MF_04119,TIGR01554,COG4653	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_174	phrog_3853	75.9	3.9e-22	N/A	unknown function
PHROG	UHGV-0033269_175	phrog_29637	59.1	6.8e-17	N/A	unknown function
PHROG	UHGV-0033269_176	phrog_31155	45.0	0.0000000000013	N/A	unknown function
structural_annotation	UHGV-0033269_176	PF19408,PF11649,NF041894,COG5614	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_177	phrog_6123	65.7	5.9e-19	virion structural protein	head and packaging
structural_annotation	UHGV-0033269_177	PF06141	N/A	N/A	N/A	N/A
PHROG	UHGV-0033269_178	phrog_4051	107.1	1.5e-31	N/A	unknown function
PHROG	UHGV-0033269_179	phrog_2729	176.0	0	virion structural protein	head and packaging
eggNOG-mapper	UHGV-0033269_179	1163671.JAGI01000002_gene1222	110.0	8.95e-26	N/A	N/A
KOfam	UHGV-0033269_182	K20283	68.8	2.4e-21	GOLGA4; golgin subfamily A member 4	N/A
PHROG	UHGV-0033269_182	phrog_4211	162.2	0	tail length tape measure protein	tail
eggNOG-mapper	UHGV-0033269_182	1541960.KQ78_01861	167.0	8.14e-39	nuclear chromosome segregation	N/A
Pfam	UHGV-0033269_182	PF10145	N/A	N/A	Phage-related minor tail protein	PhageMin_Tail
NCBIFam	UHGV-0033269_182	TIGR01760.1	N/A	N/A	phage tail tape measure protein	N/A
COG	UHGV-0033269_182	COG1196	N/A	N/A	Chromosome segregation ATPase Smc	N/A

All viral genomes

ID	Representative?	Length (bps)	% GC Content	CheckV Completeness	geNomad Score
UHGV-0033269	Yes	137,482	40	100	1
UHGV-0017694	No	137,482	40	100	1