G-quadruplex DNA conformations play crucial roles in key biological functions, including transcription, replication, telomere maintenance, and genomic instability, and have been an important component of organismal evolution.
“Quadrupia” is the largest and most comprehensive database for G-quadruplexes to date, enabling their study across the tree of life.
In our database, we provide all the G-quadruplexes identified in the genomes of 108,449 organisms using two different algorithms, resulting in 109,874,605 and 30,306,672 G-quadruplexes in total for each algorithm.
This comprehensive database is searchable and integrates motif-based and BLAST searches. Quadrupia is publicly available through https://www.pavlopoulos-lab.org/quadrupia.