A database of Novel Metagenome Protein Families

A database of Novel Metagenome Protein Clusters

A database of Novel Metagenome Protein Clusters
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Welcome to NMPFamsDB

A database of novel protein families from microbial metagenomes and metatranscriptomes

NMPFamsDB is a database which hosts novel metagenome protein clusters with no or weak hits to Pfam or Reference genomes and aiming at significantly expanding the protein family space known till today. With NPFamsDB you can:
  • Explore the novel protein families and their genomic content
  • See their habitat distribution
  • Follow their biogeographical trademarks
  • See their taxonomy information
  • Explore potential novel structures and folds
  • Use HMM and sequence-based searches for querying the protein clusters
  • Filter information by smart filters at any stage of analysis
The identified novel protein clusters, contained in NMPFamsDB, significantly expand (at least double) the number of protein sequence clusters currently available and reveal new insights into their habitat distribution, origins, functions and taxonomy. We expect NMPFamsDB to be a valuable resource for proteome-wide analysis and for the further study of metagenomes.

If you find NMPFamsDB useful in your research please cite the following two publications:

Baltoumas, F.A., Karatzas, E., Liu, S., Ovchinnikov, S., Chen, I.M, Kyrpides, N.C., Pavlopoulos, G.A.
NMPFamsDB: a database of novel protein families from microbial metagenomes and metatranscriptomes
Nucleic Acids Research (2023); gkad800, doi: 10.1093/nar/gkad800, PubMed: 37811892

Pavlopoulos, G.A., Baltoumas, F.A., Liu, S., Selvitopi, O., Camargo, A.P., Nayfach, S., Azad, A., Roux, S., Call, L., Ivanova, N.N., Chen, I.M, Paez-Espino, D., Karatzas, E., Novel Metagenome Protein Families Consortium, Iliopoulos, I., Konstantinidis, K., Tiedje, Pett-Ridge, J., J.M., Baker, D., Visel, A., Ouzounis, C.A., Ovchinnikov, S., Buluç, A., Kyrpides, N.C.
Unraveling the functional dark matter through global metagenomics
Nature (2023), doi: 10.1038/s41586-023-06583-7, PubMed: 37821698

Official press release for NMPFamsDB:

Doubling Down on Known Protein Families
Shedding light on the diversity of microbial communities by looking at protein function within them
Links: B.S.R.C. "Alexander Fleming" || D.O.E. Joint Genome Institute

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